Description
NAD-dependent protein deacetylase (PubMed: 23835326, PubMed: 17923681, PubMed: 18794531, PubMed: 21172655, PubMed: 26620563). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed: 23835326, PubMed: 17923681, PubMed: 18794531, PubMed: 21172655). Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed: 16790548, PubMed: 18794531, PubMed: 21172655). Contributes to the regulation of the cellular energy metabolism (PubMed: 23835326). Important for regulating tissue-specific ATP levels (PubMed: 18794531, PubMed: 24252090). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed: 23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (PubMed: 26620563)